Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MTO1 contributors: mct/npt/pgu - updated : 07-01-2015
HGNC name mitochondrial translation optimization 1 homolog (S. cerevisiae)
HGNC id 19261
Corresponding disease
MTO1D MTO1 deficiency
Location 6q13      Physical location : 74.171.453 - 74.211.177
Synonym name
  • homolog of yeast Mto1
  • mitochondrial MTO1-3
  • Synonym symbol(s) CGI-02
    DNA
    TYPE functioning gene
    STRUCTURE 39.73 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC340167 6q14.1 similar to hypothetical protein DKFZp434A1315 KCNQ5 6q14 potassium voltage-gated channel, KQT-like subfamily, member 5 C6orf148 6q13 chromosome 6 open reading frame 148 EIF3S6P1 6q13 eukaryotic translation initiation factor 3, subunit 6 48kDa pseudogene 1 LOC391942 6 similar to syntenin-2alpha LOC391943 6 similar to Multifunctional protein ADE2 LOC340168 6q14.1 similar to developmental pluripotency associated 5; embryonal stem cell specific gene 1 LOC154288 6q14.1 similar to RIKEN cDNA 2410004A20 RPL39P3 6q14.1 ribosomal protein L39 pseudogene 3 DDX43 6q12-q13 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 C6orf150 6q13 chromosome 6 open reading frame 150 MTO1 6q14.1 mitochondrial translation optimization 1 homolog (S. cerevisiae) EEF1A1 6q14 eukaryotic translation elongation factor 1 alpha 1 LOC389411 6 LOC389411 SLC17A5 6q14-q15 solute carrier family 17 (anion/sugar transporter), member 5 CD109 6q14.1 CD109 antigen (Gov platelet alloantigens)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 splicing 3003 79.8 717 - 2002 12011058
    12 splicing 2928 77.2 692 - 2002 12011058
    13 - 3048 - 732 - 2002 12011058
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon moderately
     liver    
    Endocrinethyroid   highly
    Hearing/Equilibriumearinnercochlea  
    Lymphoid/Immunespleen   highly
     thymus   moderately
    Nervousbrain   lowly
    Reproductivefemale systembreastmammary gland predominantly
     female systemuteruscervix moderately
    Respiratorylung   lowly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion highly in lymph
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated FlavoP
    HOMOLOGY
    interspecies homolog to rattus Mto1 (82.2 pc)
    homolog to murine Mto1 (87.4 pc)
    Homologene
    FAMILY
  • gidA family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • apparently involved in translation
  • acting as a disulfide oxidoreductase
  • may play an important role in the pathogenesis of deafness-associated A1555G mutation in 12S rRNA gene or in tRNA genes
  • involved in the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs
  • may modulate the phenotypic manifestation of deafness-associated mitochondrial mutation
  • involved in posttranscriptional modification of mitochondrial tRNAs (mt-tRNAs)
  • FAD-containing enzyme involved in posttranscriptional modification of specific mt-tRNAs, thus contributing to the optimization of mtDNA-dependent protein synthesis
  • CELLULAR PROCESS nucleotide
    protein
    PHYSIOLOGICAL PROCESS electron transport
    text
  • tRNA processing
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • FAD
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MTO1D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS