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FLASH GENE
Symbol CERK contributors: mct - updated : 12-09-2007
HGNC name ceramide kinase
HGNC id 19256
RNA
TRANSCRIPTS type messenger
text two isoforms
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 4457 - 537 - Pettus
- - 3040 - 201 - Pettus
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrineparathyroid   highly
 thyroid   highly
Lymphoid/Immunelymph node   highly
Nervousbrainmidbrainsubstantia nigra  
 ganglia    
Visualeyelens   
cell lineage
cell lines
fluid/secretion lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal pleckstrin homology (PH) domain (essential for CERK activity, binding to phosphatidylinositol phosphates and localisation to the golgi and plasma membranes) (Don 2009)
  • a calmodulin binding motif
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    text PH domain is essential for localisation to the golgi and plasma membranes (Don 2009)
    basic FUNCTION
  • playing a role in arachidonic acid release and production of eicosanoids
  • in mast cell degranulation CERK acts downstream of CALM1, similar to CALM1-dependent protein kinase II, which had been assumed to be the main target of CALM1 in mast cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text involved in lipid transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by calmodulin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS