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FLASH GENE
Symbol CEACAM6 contributors: mct - updated : 04-04-2023
HGNC name carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
HGNC id 1818
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in pancreatic adenocarcinoma
tumoral     --over  
in primary myelofibrosis (
tumoral     --over  
in borderline and invasive mucinous ovarian cancers (
tumoral     --low  
in hyperplastic polyps and early adenomas
tumoral     --over  
in gastric cancer and is correlated with lymph node metastasis
tumoral       gain of function
in metastatic osteosarcoma tissues when compared with the nonmetastatic osteosarcoma tissues
tumoral     --over  
positive association between CEACAM6 expression and poor prognosis of pancreatic cancer, differentiation and lymph node metastasis
tumoral     --over  
in human gallbladder cancer cells
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • potential prognostic indicator and potential chemoresistant marker to gemcitabine for patients with intrahepatic cholangiocarcinoma
  • could be an important biomarker of metastasis (
  • prognostic biomarker for gastric carcinoma
  • promising biomarker for the treatment of metastatic osteosarcoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential target for the development of biomarkers to predict the response of patients to adenovirus-based therapies, as well as for the development of more potent adenovirus-based therapeutics in cancer
    cancerdigestivestomach
    potential therapeutic target for gastric carcinoma
    cancerbone 
    a potential therapeutic target for the treatment of metastatic osteosarcoma
    cancerdigestiveliver
    depletion of CEACAM6 mRNA suppressed the malignant biological behaviors of human gallbladder cancer cells
    ANIMAL & CELL MODELS