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FLASH GENE

Symbol

CEACAM6

contributors: mct - updated : 04-04-2023

HGNC name	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
HGNC id	1818

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	16.72 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see CEA@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002483 6 - 2631 NP_002474 - 344 - 2009 19411761

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly   mouth tongue     highly   stomach       highly Endocrine pancreas       highly Reproductive male system prostate     moderately Respiratory lung       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic granulocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an immunoglobulin-like V-type domain
	two immunoglobulin-like C2-type domains

conjugated

GlycoP

HOMOLOGY

intraspecies

homolog to carcinoembryonic antigen

Homologene

FAMILY	immunoglobulin superfamily
	CEA subfamily

CATEGORY

adhesion , antigen , protooncogene

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	attached to the membrane by a GPI-anchor

basic FUNCTION	modulating pancreatic adenocarcinoma cellular invasiveness in a c-Src-dependent manner
	CEACAM6 and CEACAM7 expression correlated with apoptosis at the table region of the normal colon
	intercellular adhesion molecule overexpressed in a wide variety of cancers, including colon, breast and lung and associated with tumourigenesis, tumour cell adhesion, invasion and metastasis (
	unique mediator of migration and invasion of drug resistant oestrogen-deprived breast cancer cells (
	cellular protein that restricts the ability of adenoviral vectors to infect cancer cells
	can antagonize the Src signaling pathway
	implicated in cell adhesion, cellular invasiveness, angiogenesis, and inflammation, which are all key processes in the pathophysiology of primary myelofibrosis
	important positive regulator of EMT in pancreatic cancer offering an explanation for how elevated levels of CEACAM6 are likely to contribute to the highly metastatic phenotype of pancreatic cancer
	is a glycoprotein receptor for Influenza A virus

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

cell-cell signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

IFNG has two important effects on the expression levels of the CEA family molecules in colon epithelial cells: direct upregulation of CEACAM1 and promotion of cell differentiation resulting in increased expression of CEA and CEACAM6 and decreased expression of CEACAM7

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in pancreatic adenocarcinoma tumoral     --over   in primary myelofibrosis ( tumoral     --over   in borderline and invasive mucinous ovarian cancers ( tumoral     --low   in hyperplastic polyps and early adenomas tumoral     --over   in gastric cancer and is correlated with lymph node metastasis tumoral       gain of function in metastatic osteosarcoma tissues when compared with the nonmetastatic osteosarcoma tissues tumoral     --over   positive association between CEACAM6 expression and poor prognosis of pancreatic cancer, differentiation and lymph node metastasis tumoral     --over   in human gallbladder cancer cells

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	potential prognostic indicator and potential chemoresistant marker to gemcitabine for patients with intrahepatic cholangiocarcinoma
	could be an important biomarker of metastasis (
	prognostic biomarker for gastric carcinoma
	promising biomarker for the treatment of metastatic osteosarcoma
Therapy target
	System Type Disorder Pubmed cancer     potential target for the development of biomarkers to predict the response of patients to adenovirus-based therapies, as well as for the development of more potent adenovirus-based therapeutics in cancer cancer digestive stomach potential therapeutic target for gastric carcinoma cancer bone   a potential therapeutic target for the treatment of metastatic osteosarcoma cancer digestive liver depletion of CEACAM6 mRNA suppressed the malignant biological behaviors of human gallbladder cancer cells

ANIMAL & CELL MODELS