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FLASH GENE
Symbol CEACAM6 contributors: mct - updated : 04-04-2023
HGNC name carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
HGNC id 1818
Location 19q13.2      Physical location : 42.259.397 - 42.276.113
Synonym name
  • formerly nonspecific cross-reacting antigen
  • normal cross-reacting antigen
  • CD66c antigen
    • Synonym symbol(s) NCA, CEAL, CD66c
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 16.72 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see CEA@
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2631 - 344 - 2009 19411761
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     mouthtongue  highly
     stomach   highly
    Endocrinepancreas   highly
    Reproductivemale systemprostate  moderately
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticgranulocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an immunoglobulin-like V-type domain
  • two immunoglobulin-like C2-type domains
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to carcinoembryonic antigen
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CEA subfamily
    • CATEGORY adhesion , antigen , protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text attached to the membrane by a GPI-anchor
    basic FUNCTION
  • modulating pancreatic adenocarcinoma cellular invasiveness in a c-Src-dependent manner
  • CEACAM6 and CEACAM7 expression correlated with apoptosis at the table region of the normal colon
  • intercellular adhesion molecule overexpressed in a wide variety of cancers, including colon, breast and lung and associated with tumourigenesis, tumour cell adhesion, invasion and metastasis (
  • unique mediator of migration and invasion of drug resistant oestrogen-deprived breast cancer cells (
  • cellular protein that restricts the ability of adenoviral vectors to infect cancer cells
  • can antagonize the Src signaling pathway
  • implicated in cell adhesion, cellular invasiveness, angiogenesis, and inflammation, which are all key processes in the pathophysiology of primary myelofibrosis
  • important positive regulator of EMT in pancreatic cancer offering an explanation for how elevated levels of CEACAM6 are likely to contribute to the highly metastatic phenotype of pancreatic cancer
  • is a glycoprotein receptor for Influenza A virus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    cell-cell signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IFNG has two important effects on the expression levels of the CEA family molecules in colon epithelial cells: direct upregulation of CEACAM1 and promotion of cell differentiation resulting in increased expression of CEA and CEACAM6 and decreased expression of CEACAM7
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic adenocarcinoma
    tumoral     --over  
    in primary myelofibrosis (
    tumoral     --over  
    in borderline and invasive mucinous ovarian cancers (
    tumoral     --low  
    in hyperplastic polyps and early adenomas
    tumoral     --over  
    in gastric cancer and is correlated with lymph node metastasis
    tumoral       gain of function
    in metastatic osteosarcoma tissues when compared with the nonmetastatic osteosarcoma tissues
    tumoral     --over  
    positive association between CEACAM6 expression and poor prognosis of pancreatic cancer, differentiation and lymph node metastasis
    tumoral     --over  
    in human gallbladder cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential prognostic indicator and potential chemoresistant marker to gemcitabine for patients with intrahepatic cholangiocarcinoma
  • could be an important biomarker of metastasis (
  • prognostic biomarker for gastric carcinoma
  • promising biomarker for the treatment of metastatic osteosarcoma
    • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential target for the development of biomarkers to predict the response of patients to adenovirus-based therapies, as well as for the development of more potent adenovirus-based therapeutics in cancer
    cancerdigestivestomach
    potential therapeutic target for gastric carcinoma
    cancerbone 
    a potential therapeutic target for the treatment of metastatic osteosarcoma
    cancerdigestiveliver
    depletion of CEACAM6 mRNA suppressed the malignant biological behaviors of human gallbladder cancer cells
    ANIMAL & CELL MODELS