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FLASH GENE
Symbol PSAT1 contributors: mct - updated : 07-10-2014
HGNC name phosphoserine aminotransferase 1
HGNC id 19129
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • besides a small C-terminal domain, each subunit contains a large pyridoxal 5¡ä-phosphate (PLP) binding domain implicated in the protein¨Cprotein interactions between the subunit
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine PSAT1
    homolog to rattus LOC293820
    Homologene
    FAMILY
  • class V pyridoxal phosphate dependent aminotransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzes the transamination of 3-phosphohydroxypyruvate to 3-phosphoserine with glutamate as amino donor
  • required in pathways of serine and pyridoxine biosynthesis
  • enzyme playing a role in the L-serine biosynthesis which could be implicated in colon cancer progression and chemoresistance
  • can transaminate glyoxylate with good efficiency, using L-glutamate as the best amino-group donor
  • promoted cell cycle progression, cell proliferation and tumorigenesis
  • enzyme for the second step in L-serine biosynthesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    three-enzyme serine biosynthesis pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pyridoxal phosphate
    • protein
  • PRKCZ represses the expression of PHGDH and PSAT1, and phosphorylates PHGDH at key residues to inhibit its enzymatic activity
    • cell & other
    REGULATION
    Other expression of mRNA is up-regulated during S phase
    ASSOCIATED DISORDERS
    corresponding disease(s) PSATD , NELAS2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in colon tumors
    tumoral     --over  
    in non-small cell lung cancer (NSCLC) and was involved in the regulation of E2F activity
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target represents a new interesting target for colorectal cancer therapy
    ANIMAL & CELL MODELS