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FLASH GENE
Symbol EBF3 contributors: mct - updated : 02-03-2017
HGNC name early B-cell factor 3
HGNC id 19087
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
C5-type zinc finger, serine/threonine/proline rich domain
mono polymer homomer , heteromer , dimer
HOMOLOGY
Homologene
FAMILY
  • Olf/EBF family of helix-loop-helix transcription factors
  • early B cell factor family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • regulates neurogenesis and differenciation
  • regulates a transcriptional program underlying a putative tumor suppression pathway
  • keystone in the regulatory network that coordinates B cell lineage specification and commitment (Lukin 2008)
  • tumor suppressors whose inactivation blocks normal development and contributes to tumorigenesis of diverse types of cancer (Liao 2009)
  • activates genes involved in cell cycle arrest and inhibits cell survival
  • both EBF2 and EBF3, singly or together, control the migration of Cajal-Retzius (CR) cells arising in the cortical hem, and Ebfs directly regulate CR cell development
  • is a new regulator of terminal muscle differentiation in the diaphragm, and EBF factors cooperate with MYOD1 in the induction of muscle-specific genes
  • may act as a putative tumor suppressor gene in pediatric acute myeloid leukemia (AML)
  • atypical transcription factor that is thought to influence the laminar formation of the cerebral cortex
  • is a critical regulator of inhibitory GABAergic neuronal development
  • transcription factor involved in neuronal differentiation and maturation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • transcription of DSCR4 gene is regulated positively by binding of OLF1-like transcription factor EBF3, EBF4 and negatively by binding of E47-like transcription factor
  • FOXG1 binds to mammalian-specific noncoding sequences to repress over 12 transcription factors expressed in early progenitors, including EBF2/3, DMRT3, DMRTA1, and EYA2
  • bound directly to CDKN1A promoter and regulated transcription from both CDKN1A and CDKN1B promoters
  • NEUROG2, NEUROD1, and EBF3 inducing MTURN
  • binds directly to the promoter of ATP2A1 and synergises with MYOD1 in the induction of ATP2A1
  • is a downstream transcriptional target of aristaless-related homeobox (ARX) and is thought to be transcriptionally repressed by ARX
  • EBF3 is a PRDM8 target gene, and EBF3 is a key regulator of neuronal migration via multipolar-to-bipolar transition
    • cell & other
    REGULATION
    repressed by aberrant methylation
    ASSOCIATED DISORDERS
    corresponding disease(s) HADDS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    silenced in brain tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serves as an independent prognostic marker in gastric carcinoma
    • Therapy target
    ANIMAL & CELL MODELS