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FLASH GENE
Symbol NCR3 contributors: mct - updated : 08-03-2012
HGNC name natural cytotoxicity triggering receptor 3
HGNC id 19077
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an Ig type V domain
  • a critical ligand binding region involving its F strand
  • conjugated GlycoP
    mono polymer complex
    HOMOLOGY
    interspecies ortholog to chimpanzee ncr3
    homolog to rattus ncr3
    Homologene
    FAMILY
  • natural cytotoxicity receptor (NCR) family
  • CD28 family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • play a predominant role in natural killer cell activation during the process of natural cytotoxicity against most tumor target cells
  • stimulatory receptor on NK cells implicated in tumor immunity, and is capable of promoting or terminating dendritic cell maturation
  • may play an important role during alloactivation
  • critical and differential roles of NCR1- and NCR3-activating receptors expressed by uterine NK cells in early pregnancy
  • NCR1, NCR2, NCR3 are thought to be NK lineage restricted
  • with NCR2 and NCR1, are type I transmembrane proteins that signal NK cell activation via ITAM-containing adapter proteins in response to stress- and pathogen-induced ligands
  • recognizes B7H6, a member of the B7 family which is expressed on tumor, but not healthy, cells
  • critical for the elimination of a large group of tumor cell types
  • involved in the recognition of tumor and dendritic cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling
    a component forms a complex with CD3 zeta chain
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically associated with CD59 to activate NK-cell mediated cytotoxicity
  • CD3Z
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism SNP three SNP (-201G>A, -163G>C, c.111G>A) and a rare variation (c.156C>T) in Japanese population
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS