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FLASH GENE

Symbol

NCR3

contributors: mct - updated : 08-03-2012

HGNC name	natural cytotoxicity triggering receptor 3
HGNC id	19077

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	4.10 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_147130 4 - 1054 NP_667341 - 201 - 2011 21552268 Nkp30a NM_001145466 4 - 1109 NP_001138938 - 177 - 2011 21552268 Nkp30b NM_001145467 4 - 875 NP_001138939 - 190 - 2011 21552268 Nkp30c predominant expression of the immunosuppressive NKp30c isoform (over the immunostimulatory NKp30a and NKp30b isoforms) associated with reduced survival, in gastrointestinal sarcoma

EXPRESSION

Rna function	mRNA was significantly up-regulated in fresh tissues during late secretory phase of the menstrual cycle
Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node           spleen         Reproductive female system uterus       Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Epithelial barrier lining endometrium     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune natural killer Reproductive epithelial cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an Ig type V domain
	a critical ligand binding region involving its F strand

conjugated

GlycoP

mono polymer

complex

HOMOLOGY

interspecies	ortholog to chimpanzee ncr3
	homolog to rattus ncr3

Homologene

FAMILY	natural cytotoxicity receptor (NCR) family
	CD28 family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	play a predominant role in natural killer cell activation during the process of natural cytotoxicity against most tumor target cells
	stimulatory receptor on NK cells implicated in tumor immunity, and is capable of promoting or terminating dendritic cell maturation
	may play an important role during alloactivation
	critical and differential roles of NCR1- and NCR3-activating receptors expressed by uterine NK cells in early pregnancy
	NCR1, NCR2, NCR3 are thought to be NK lineage restricted
	with NCR2 and NCR1, are type I transmembrane proteins that signal NK cell activation via ITAM-containing adapter proteins in response to stress- and pathogen-induced ligands
	recognizes B7H6, a member of the B7 family which is expressed on tumor, but not healthy, cells
	critical for the elimination of a large group of tumor cell types
	involved in the recognition of tumor and dendritic cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense , inflammation

PATHWAY

metabolism

signaling

a component

forms a complex with CD3 zeta chain

INTERACTION

DNA

RNA

small molecule

protein	physically associated with CD59 to activate NK-cell mediated cytotoxicity
	CD3Z

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism SNP	three SNP (-201G>A, -163G>C, c.111G>A) and a rare variation (c.156C>T) in Japanese population

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS