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FLASH GENE
Symbol PDCD1LG2 contributors: mct - updated : 19-11-2014
HGNC name programmed cell death 1 ligand 2
HGNC id 18731
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal sequence, igV6 AND igC6 like domains
  • a transmembrane region
  • a cytoplasmic region
    • HOMOLOGY
    interspecies homolog to Drosophila Cg9302
    homolog to C.elegans C14b9.2
    homolog to murine Pdl2
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • BTN/MOG family
    • CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • ligand of PDL1, inhibiting T cell activation
  • dendritic cell molecule with costimulatory properties for T cells
  • play with its ligand an important role in the negative regulation of immune reactions
  • expressed following activation and is involved in the regulation of T cell function, highlighting the level of complexity in the T cell cosignaling network
  • its expression is involved in brain endothelial cells contribution to control T cell transmigration into the CNS
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    signaling via CD274 and PDCD1LG2 is crucial for maintaining peripheral tolerance
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to PDCD1
  • PDCD1-PDCDlLG2 interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma
  • differential molecular mechanisms of interaction of CD274 and PDCD1LG2 with PDCD1, suggesting possible new approach for the therapy of chronic infection, cancer and transplantation (
  • PDCD1 is a potent inhibitory receptor of T cells which binds to two different ligands, namely CD274 and PDCD1LG2, and upon binding, it inhibits T cell activation, differentiation, and proliferation, leading to a state of immune tolerance
    • cell & other
    REGULATION
    activated by gamma-interferon (IFNG) in monocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    of endothelium PDCD1LG2 levels in multiple sclerosis
    constitutional     --over  
    as a costimulatory molecule, may have an important modulatory function on the local immune responses of oral lichen planus (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS