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FLASH GENE

Symbol

PDCD1LG2

contributors: mct - updated : 19-11-2014

HGNC name	programmed cell death 1 ligand 2
HGNC id	18731

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver       highly Endocrine pancreas       highly   placenta       highly Lymphoid/Immune lymph node       lowly   thymus       lowly Nervous brain         Homo sapiens Respiratory lung       highly

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Homo sapiens Lymphoid/Immune dendritic cell Lymphoid/Immune T cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal sequence, igV6 AND igC6 like domains
	a transmembrane region
	a cytoplasmic region

HOMOLOGY

interspecies	homolog to Drosophila Cg9302
	homolog to C.elegans C14b9.2
	homolog to murine Pdl2

Homologene

FAMILY	immunoglobulin superfamily
	BTN/MOG family

CATEGORY

immunity/defense , regulatory

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	ligand of PDL1, inhibiting T cell activation
	dendritic cell molecule with costimulatory properties for T cells
	play with its ligand an important role in the negative regulation of immune reactions
	expressed following activation and is involved in the regulation of T cell function, highlighting the level of complexity in the T cell cosignaling network
	its expression is involved in brain endothelial cells contribution to control T cell transmigration into the CNS

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

signaling via CD274 and PDCD1LG2 is crucial for maintaining peripheral tolerance

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to PDCD1
	PDCD1-PDCDlLG2 interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma
	differential molecular mechanisms of interaction of CD274 and PDCD1LG2 with PDCD1, suggesting possible new approach for the therapy of chronic infection, cancer and transplantation (
	PDCD1 is a potent inhibitory receptor of T cells which binds to two different ligands, namely CD274 and PDCD1LG2, and upon binding, it inhibits T cell activation, differentiation, and proliferation, leading to a state of immune tolerance

cell & other

REGULATION

activated by

gamma-interferon (IFNG) in monocytes

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   of endothelium PDCD1LG2 levels in multiple sclerosis constitutional     --over   as a costimulatory molecule, may have an important modulatory function on the local immune responses of oral lichen planus (

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS