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FLASH GENE
Symbol PDCD1LG2 contributors: mct - updated : 19-11-2014
HGNC name programmed cell death 1 ligand 2
HGNC id 18731
Location 9p24.1      Physical location : 5.510.544 - 5.571.281
Synonym name
  • programmed death ligand 2
  • PD-1-ligand 2
  • butyrophilin B7-DC
  • Synonym symbol(s) PD-L2, Btdc, B7DC, CD273, MGC142238, MGC142240, PD-L2, PDCD1L2, PDL2
    DNA
    TYPE functioning gene
    STRUCTURE 60.74 kb     7 Exon(s)
    regulatory sequence Promoter
    text structure
  • its expression is regulated by two different promoters that function in a lineage-specific manner, with the B-1-specific promoter being constitutively active as a result of POU2F1 and POU2F2 binding
  • MAPPING cloned Y linked N status provisional
    Physical map
    ZNF515 9p24.2 zinc finger protein 515 C9orf70 9p24.2 chromosome 9 open reading frame 70 SLC1A1 9p24 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 C9orf68 9p24.2 chromosome 9 open reading frame 68 HARC 9p24.1 chromosome 9 open reading frame 68 AK3L1 9p24.1-p24.3 adenylate kinase 3 like 1 LOC392282 9 similar to ribosomal protein S5 RCL1 9p24.1-p23 RNA terminal phosphate cyclase-like 1 JAK2 9p24 Janus kinase 2 (a protein tyrosine kinase) INSL6 9p24 insulin-like 6 INSL4 9p24.1-p23.3 insulin-like 4 (placenta) RLN2 9pter-q12 relaxin 2 (H2) RLN1 9pter-q12 relaxin 1 (H1) C9orf46 9p24.1 chromosome 9 open reading frame 46 PDCD1LG1 9p24 programmed cell death 1 ligand 1 PDCD1LG2 9p24.2 programmed cell death 1 ligand 2 KIAA1432 9p24.1 KIAA1432 KIAA1815 9p24 KIAA1815 MLANA 9p24.1 melan-A KIAA2026 9p24.1 KIAA2026 RANBP6 12p13.31 RAN binding protein 6 C9orf26 9p24.1 chromosome 9 open reading frame 26 (NF-HEV) LOC389704 9 similar to Selenoprotein T NYD-SP25 9p24.1 protein kinase NYD-SP25 NIRF 9p24.1 Np95-like ring finger protein C9orf38 9p24.1 chromosome 9 open reading frame 38 GLDC 9p24-p23 glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P) LOC392283 9 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 LOC392284 9 hypothetical gene supported by AK091574 GASC1 9p24-p23 hypothetical gene supported by AK091574 LOC158352 9p24.1 similar to small nuclear ribonucleoprotein E LOC158345 9p24.1 similar to ribosomal protein L4; 60S ribosomal protein L4; homologue of Xenopus ribosomal protein L1 LOC392285 9 similar to peptidyl-Pro cis trans isomerase
    regionally located located in close proximity to the PDL1 gene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2418 - 273 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinepancreas   highly
     placenta   highly
    Lymphoid/Immunelymph node   lowly
     thymus   lowly
    Nervousbrain     Homo sapiens
    Respiratorylung   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    Lymphoid/Immunedendritic cell
    Lymphoid/ImmuneT cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal sequence, igV6 AND igC6 like domains
  • a transmembrane region
  • a cytoplasmic region
  • HOMOLOGY
    interspecies homolog to Drosophila Cg9302
    homolog to C.elegans C14b9.2
    homolog to murine Pdl2
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • BTN/MOG family
  • CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • ligand of PDL1, inhibiting T cell activation
  • dendritic cell molecule with costimulatory properties for T cells
  • play with its ligand an important role in the negative regulation of immune reactions
  • expressed following activation and is involved in the regulation of T cell function, highlighting the level of complexity in the T cell cosignaling network
  • its expression is involved in brain endothelial cells contribution to control T cell transmigration into the CNS
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    signaling via CD274 and PDCD1LG2 is crucial for maintaining peripheral tolerance
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to PDCD1
  • PDCD1-PDCDlLG2 interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma
  • differential molecular mechanisms of interaction of CD274 and PDCD1LG2 with PDCD1, suggesting possible new approach for the therapy of chronic infection, cancer and transplantation (
  • PDCD1 is a potent inhibitory receptor of T cells which binds to two different ligands, namely CD274 and PDCD1LG2, and upon binding, it inhibits T cell activation, differentiation, and proliferation, leading to a state of immune tolerance
  • cell & other
    REGULATION
    activated by gamma-interferon (IFNG) in monocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    of endothelium PDCD1LG2 levels in multiple sclerosis
    constitutional     --over  
    as a costimulatory molecule, may have an important modulatory function on the local immune responses of oral lichen planus (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS