| basic FUNCTION
| serine/threonine and tyrosine kinase involved in post-embryonic neurogenesis |
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putatively involved in cell growth and development |
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playing a role in controlling motor function and may be implicated in Down syndrome motor dysfunction |
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involved in the signaling mechanisms that regulate dendrite differentiation |
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involved with RCAN1 in the cooperative destabilization of a regulatory circuit, leading to reduced NFATc activity |
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may play a role in a signaling pathway regulating nuclear functions of cell proliferaration |
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could be responsible for learning and memory deterioration in Down syndrome and of memory impairment in ALzheimer disease |
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playing a physiological role in the hyperphosphorylation of Tau responsible of insoluble deposits in Alzheimer disease |
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playing an important, but diverse from developmental role in adult central nervous system  |
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inhibiting the expression of REST(a key regulator of pluripotency and neuronal differentiation), an alteration that persists in trisomy 21 from undifferentiated embryonic stem (ES) cells to adult brain (deregulation of REST is a very early pathological consequence of trisomy 21 with potential to disturb the development of all embryonic lineages) |
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negative regulator of the intrinsic apoptotic pathway in the developing retina (phosphorylates caspase-9 on threonine residue 125, and this phosphorylation event is crucial to protect retina cells from apoptotic cell death) |
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positively regulates FGF-mitogen-activated protein kinase signaling by phosphorylation-dependent impairment of the inhibitory activity of SPRY2 |
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might modulate the hypertrophic response of cardiomyocytes |
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promotes cell survival through phosphorylation and activation of SIRT1 with DYRK3 |
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role in controlling synaptic vesicle recycling processes |
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role of DYRK1A in the regulation of neurite formation |
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DYRK1A, DYRK2, and DYRK4 phosphorylate distinct although overlapping sets of the 720 different peptides in the phosphosite array |
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DYRK1A and REST are closely related in neurodevelopment |
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DYRK1A, DYRK3, DYRK4 implicated in the regulation of cytoskeletal organization and process outgrowth in neurons |
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plays a role in many cellular pathways through phosphorylation of diverse substrate proteins |
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implication of DYRK1A overexpression in a developmental alteration of the central nervous system associated with Down syndrome (DS), thereby providing insights into the aetiology of neurosensorial dysfunction in a complex disease |
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DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing CCND3 |
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dose-specific DYRK1A expression and activity appears to be critical for the hyperplastic and hypertrophic growth of the developing heart |
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DYRK1A expression decreases cell survival efficiency in response to DNA damage, suggesting a tumor suppressive role for this kinase |
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is important for both kidney development and function |
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dual kinase that can phosphorylate its own activation loop on tyrosine residue and phosphorylate its substrates on threonine and serine residues |
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DYRK1A and CEP97 coordinate with PLK1 to promote Separase function to properly form multicilia in multiciliated cells (MCCs) |
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involved in many biological processes during development and in adulthood |
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plays a role in major developmental steps of brain development, controlling the proliferation of neural progenitors, the migration of neurons, their dendritogenesis and the function of the synapse |
