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FLASH GENE
Symbol ISL2 contributors: mct - updated : 23/12/2008
HGNC name ISL LIM homeobox 2
HGNC id 18524
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N-terminal LIM domains
  • a conserved cysteine- and histidine-rich structure of two tandem repeated zinc fingers (LIM domain is involved in protein-protein interactions during transcriptional regulation)
  • an homeodomain
    • secondary structure
    HOMOLOGY
    interspecies homolog to rattus Isl2
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcription factor defining subclasses of motoneurons (that segregate into columns in the spinal cord and select distinct axon pathways)
  • may be involved in both differentiation and maintenance of the tissues and might play an important role
  • playing a prominent role in specifying retinal ganglion cell laterality
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • repressing ZIC2 for control of binocular vision
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS