| protein
| MIA2 acts as a coreceptor of MIA3 for collagen VII export from the ER  |
|
PREB recruitment to ER exit sites is organized by its direct interaction with MIA2, a previously characterized collagen cargo receptor component, which functions together with MIA3 at ER exit sites |
|
general role for MIA3 in the export of bulky cargoes from the ER and specific requirement for MIA2 in assisting MIA3 to export bulky lipid particles |
|
recruitment of PREB by MIA2 contributes to efficient activation of SAR1A in the vicinity of ER exit sites |
|
interacts with components of the ER coat protein complex II (COPII) which, when depleted, also cause lipid accumulation in hepatocytes |
|
MIA3 recruits membrane-bound macromolecular complexes consisting of MIA2 and PREB to the ER exit sites |
|
MIA2/MIA3 complex interacts with the GEF and the GAP of SAR1A and tightly regulates its GTPase cycle to accomplish large cargo secretion |
|
MIA2 interacts with vesicle membrane soluble N-ethyl-maleimide sensitive factor attachment protein receptor SEC22B and this interaction with MIA2 is essential for proinsulin processing |
