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FLASH GENE
Symbol ERP44 contributors: mct/ - updated : 11-05-2016
HGNC name endoplasmic reticulum protein 44
HGNC id 18311
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three thioredoxin domains-a, b and b'-are arranged in a clover-like structure
  • conserved histidine residues in the C-terminal tail regulate ERP44
    • HOMOLOGY
    interspecies homolog to murine Txndc4
    homolog to rattus LOC298066
    Homologene
    FAMILY
  • thioredoxin family (TRX)
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • soluble protein of the ER lumen
  • is an ER lumenal chaperone protein that favors the maturation of disulfide-linked oligomeric proteins
    • basic FUNCTION
  • soluble protein of the thioredoxin family (TRX) endowed with an ER-localization signal and implicated also in ER calcium homeostasis
  • may be involved in electron transport, protein folding, response to unfolded protein, glycoprotein metabolism, secretory pathway
  • may be involved in the control of oxidative protein folding
  • play a role of the ERp44 C-tail in regulating substrate binding and release during protein quality control in the early secretory apparatus
  • ERP44 favors maturation of disulfide-linked oligomeric proteins
  • ERP44 together with ERO1A plays an important role in disulfide formation of SLC6A4, which may be a prerequisite step for the assembly of SLC6A4 molecules in oligomeric form
  • pH-regulated chaperone of the secretory pathway
  • endogenous ERP44 is O-glycosylated and secreted by human primary endometrial cells, suggesting possible pathophysiological roles of these processes
  • plays a critical role in embryonic heart development and is crucial in regulating cardiac cell Ca(2+) signaling, ER stress, ROS-induced oxidative stress, and activation of the intrinsic mitochondrial apoptosis pathway
  • endoplasmic reticulum (ER) chaperone ERP44 retains adiponectin in the early secretory compartment and tightly controls the oxidative state of Cys(39) and the oligomerization of adiponectin
    • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interactions with PDIA2 and LMAN1 provide a novel, dynamic control of SUMF1 trafficking and enzymatic activity
  • PPARG is an essential regulatory factor for the transcriptional activity of ERP44, which in turn controls the secretion of adiponectin
  • potential ability of ERP44 to inhibit ERO1A activity may suggest its physiological role in ER redox and protein homeostasis
  • involvement of ERP44 in maturation of SLC6A4
  • plays a critical role in the release of proteins from the ER via binding to ERO1A
  • PDIA2 binds preferentially ERO1A, whereas ERP44 equally retains ERO1A and PRDX4
  • AGT is regulated by ERP44, a factor involved in disulfide bond formation in the ER
  • ERP44 controls the release of ERAP1 in a redox-dependent manner to control blood pressure
    • cell & other
    REGULATION
    induced by ER stress
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • deletion of ERp44 in mouse and zebrafish caused significant embryonic lethality, abnormal heart development, altered Ca(2+) dynamics, reactive oxygen species generation, activated ER stress gene profiles, and apoptotic cell death