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FLASH GENE

Symbol

BANK1

contributors: mct - updated : 06-05-2015

HGNC name	B-cell scaffold protein with ankyrin repeats 1
HGNC id	18233

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	4q24      Physical location : 102.711.763 - 102.995.967
Synonym symbol(s)	BANK, FLJ20706, FLJ34204

DNA

TYPE	functioning gene
STRUCTURE	284.20 kb     17 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017935 17 - 3455 NP_060405 89 785 - 2008 18204447 NM_001083907 17 - 3224 NP_001077376 - 755 - 2008 18204447 differ by 30 amino acids at the N terminus, encoded by the alternative exon 1A NM_001127507 16 - 3056 NP_001120979 - 652 - 2008 18204447

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly   spleen       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Lymphoid/Immune B cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	ankyrin repeats
	an ITPR binding domain

HOMOLOGY

Homologene

FAMILY

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	pancreatic ribonuclease and oxidoreductase activities
	scaffold protein regulating BCR-induced calcium mobilization by connecting PTKs to ITPR1
	B-cell adaptor protein
	previously unrecognized role for BANK1 in CpG-induced responses by splenic B cells on MAPK14 signaling and control of translation initiation of IL6 via MKNK1/MKNK2 and EIF4E

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

molecular switch PLCG2 interacts with BANK1 and the interaction is promoted by B-cell receptor (BCR) stimulation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     BANK1-IGH-associated translocation t(4;14)(q24;q32) suggests a tumor suppressor role in B-cell lymphoma

Susceptibility

to systemic lupus erythematosus

Variant & Polymorphism other	increasing the risk of systemic lupus erythematosus

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS