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FLASH GENE
Symbol SHC3 contributors: - updated : 20-10-2004
HGNC name src homology 2 domain containing transforming protein C3
HGNC id 18181
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a phosphotyrosine interaction (PTB/PID) domain
  • a CH1 region containing tyrosine phosphorylation sites and putative SH3-binding sites
  • a Src homology 2 (SH2) domain
    • HOMOLOGY
    interspecies homolog to murine Shc3
    homolog to rattus Shc3
    Homologene
    FAMILY Shc family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in the nerve-growth factor signaling through its binding to activated tyrosine kinase receptors
  • inhibits apoptosis by coupling Ret to the PI3K/Akt signaling pathway
  • its activation might give additional effects on malignant tumor progression of neuroblastoma
  • mediates neurotrophin and other neuronal signalings in the central nervous system
    • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to GRB2
  • interacting with activated EGF receptors
  • interacting with beta-amyloid precursor protein
    • cell & other
    REGULATION
    activated by Ret
    Other tyrosine phosphorylated
    potent substrate of the activated Akt kinase
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS