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FLASH GENE

Symbol

SHC3

contributors: - updated : 20-10-2004

HGNC name	src homology 2 domain containing transforming protein C3
HGNC id	18181

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q22.1      Physical location : 91.620.685 - 91.793.682
Synonym name	neuronal Shc
Synonym symbol(s)	NSHC, SHCC

DNA

TYPE	functioning gene
STRUCTURE	165.00 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain cerebral cortex   highly   brain hindbrain medulla oblongata   lowly   brain hindbrain cerebellum   lowly   brain diencephalon thalamus   lowly   brain diencephalon hypothalamus   lowly   brain diencephalon amygdala   highly   brain basal nuclei putamen   lowly   brain basal nuclei corpus callosum   lowly   brain basal nuclei caudate nucleus   highly   brain midbrain substantia nigra   lowly

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage
cell lines	SK-N-BE(2) neuroblastoma
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a phosphotyrosine interaction (PTB/PID) domain
	a CH1 region containing tyrosine phosphorylation sites and putative SH3-binding sites
	a Src homology 2 (SH2) domain

HOMOLOGY

interspecies	homolog to murine Shc3
	homolog to rattus Shc3

Homologene

FAMILY

Shc family

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	involved in the nerve-growth factor signaling through its binding to activated tyrosine kinase receptors
	inhibits apoptosis by coupling Ret to the PI3K/Akt signaling pathway
	its activation might give additional effects on malignant tumor progression of neuroblastoma
	mediates neurotrophin and other neuronal signalings in the central nervous system

CELLULAR PROCESS	cell life, antiapoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to GRB2
	interacting with activated EGF receptors
	interacting with beta-amyloid precursor protein

cell & other

REGULATION

activated by

Ret

Other	tyrosine phosphorylated
	potent substrate of the activated Akt kinase

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS