Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CD244 contributors: mct - updated : 16-02-2016
HGNC name CD244 molecule, natural killer cell receptor 2B4
HGNC id 18171
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 spleen   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Lymphoid/Immunenatural killer
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • leader sequence with two Ig-like motifs
  • eight potential N-linked glycosylation sites
  • a transmembrane domain
  • two Ig-like (immunoglobulin-like) domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus cd244
    ortholog to murine Cd244
    intraspecies homolog to CD2 family
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • implicated in the regulation of NK and T-cell function, activates NK cytolytic activity
  • causing impaired CD244 function in NK-cells
  • SLAMF1, CD48, CD84, CD244, LY9, SLAMF6, SLAMF7 play an essential and non-redundant role in the control of humoral immune responses
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds CD48
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LYP
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS