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FLASH GENE
Symbol CD244 contributors: mct - updated : 16-02-2016
HGNC name CD244 molecule, natural killer cell receptor 2B4
HGNC id 18171
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2481 41 365 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 spleen   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Lymphoid/Immunenatural killer
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • leader sequence with two Ig-like motifs
  • eight potential N-linked glycosylation sites
  • a transmembrane domain
  • two Ig-like (immunoglobulin-like) domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus cd244
    ortholog to murine Cd244
    intraspecies homolog to CD2 family
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • implicated in the regulation of NK and T-cell function, activates NK cytolytic activity
  • causing impaired CD244 function in NK-cells
  • SLAMF1, CD48, CD84, CD244, LY9, SLAMF6, SLAMF7 play an essential and non-redundant role in the control of humoral immune responses
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds CD48
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LYP
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS