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FLASH GENE
Symbol CD244 contributors: mct - updated : 16-02-2016
HGNC name CD244 molecule, natural killer cell receptor 2B4
HGNC id 18171
Corresponding disease
LYP lymphoproliferative syndrome
Location 1q23.3      Physical location : 160.799.950 - 160.832.692
Synonym name
  • NK cell activation inducing ligand NAIL
  • CD244 natural killer cell receptor 2B4
  • CD244 antigen
    • Synonym symbol(s) 2B4, NAIL, NKR2B4, Nmrk, SLAMF4
    DNA
    TYPE functioning gene
    STRUCTURE 32.70 kb     9 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2481 41 365 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
     spleen   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Lymphoid/Immunenatural killer
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • leader sequence with two Ig-like motifs
  • eight potential N-linked glycosylation sites
  • a transmembrane domain
  • two Ig-like (immunoglobulin-like) domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus cd244
    ortholog to murine Cd244
    intraspecies homolog to CD2 family
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • implicated in the regulation of NK and T-cell function, activates NK cytolytic activity
  • causing impaired CD244 function in NK-cells
  • SLAMF1, CD48, CD84, CD244, LY9, SLAMF6, SLAMF7 play an essential and non-redundant role in the control of humoral immune responses
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds CD48
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LYP
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS