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FLASH GENE
Symbol SGPP1 contributors: shn/npt - updated : 19-01-2010
HGNC name sphingosine-1-phosphate phosphatase 1
HGNC id 17720
Location 14q23.2      Physical location : 64.150.936 - 64.194.756
Synonym name sphingosine-1-phosphatase
Synonym symbol(s) SPPase, S1P, SPPase1, Spp1
EC.number 3.1.3.-
DNA
TYPE functioning gene
STRUCTURE 43.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D14S1012 - D14S1001 - SGPP1 - D14S992 - D14S63 - qter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 3323 - 441 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinnercochlea highly
Lymphoid/Immunelymph node   highly
Reproductivefemale systemplacenta  highly
Urinarybladder   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines HEK293, MCF-7
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text kidney, placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six to eight transmembrane segments
  • three conserved motifs, KXXXXXXRP, SXH, SRXXXXXHXXXD
  • HOMOLOGY
    interspecies ortholog to Sgpp1, Rattus norvegicus
    ortholog to Sgpp1, Mus musculus
    ortholog to sgpp1, Danio rerio
    Homologene
    FAMILY
  • type 2 lipid phosphate phosphatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • having enzymatic activity against both sphingosine 1 phosphate (S1P) and dihydro-S1P
  • playing a role in the regulation of intra and extracellular sphingosine 1 phosphate levels and cell viability
  • may have a role in cell proliferation, angiogenesis and apoptosis through the sphingosine 1 phosphate levels regulation
  • missing cofactor for TRAF2, an E3 ligase that has an important role in Lys-63-linked polyubiquitination of RIPK1 and consequent regulation of NFKB activation
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS