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FLASH GENE

Symbol

MTCH2

contributors: mct/shn/pgu - updated : 19-09-2015

HGNC name	mitochondrial carrier homolog 2 (C. elegans)
HGNC id	17587

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Knockout of MTCH2/MIMP in embryonic stem cells and in mouse embryonic fibroblasts hinders the recruitment of truncated BID protein to mitochondria, the activation of Bax/Bak, mitochondrial outer membrane permeabilization and apoptosis
	MTCH2/MIMP conditional knockout in liver decreases the sensitivity of mice to Fas-induced hepatocellular apoptosis and prevents the recruitment of tBID to liver mitochondria