Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

MTCH2

contributors: mct/shn/pgu - updated : 19-09-2015

HGNC name	mitochondrial carrier homolog 2 (C. elegans)
HGNC id	17587

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism	associated with body mass index

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Knockout of MTCH2/MIMP in embryonic stem cells and in mouse embryonic fibroblasts hinders the recruitment of truncated BID protein to mitochondria, the activation of Bax/Bak, mitochondrial outer membrane permeabilization and apoptosis
	MTCH2/MIMP conditional knockout in liver decreases the sensitivity of mice to Fas-induced hepatocellular apoptosis and prevents the recruitment of tBID to liver mitochondria