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FLASH GENE
Symbol MTCH2 contributors: mct/shn/pgu - updated : 19-09-2015
HGNC name mitochondrial carrier homolog 2 (C. elegans)
HGNC id 17587
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six transmembrane domains
  • an energy transfer signature motif
    • HOMOLOGY
    interspecies ortholog to MTCH2, Pan troglodytes
    ortholog to Mtch2, Mus musculus
    ortholog to Mtch2, Rattus norvegicus
    ortholog to mtch2, Danio rerio
    Homologene
    FAMILY
  • mitochondrial carrier family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    text a surface-exposed outer mitochondrial membrane protein
    basic FUNCTION
  • mitochondrial target of truncated BID and this MTCH2-resident complex participates in the mitochondrial apoptotic program
  • mitochondrial carrier homologue upregulated by Met-hepatocyte growth factor (HGF) signal transduction, which leads to mitochondrial depolarization
  • a critical role in liver apoptosis by regulating the recruitment of tBID to mitochondria
  • has a major role in the mitochondrial outer membrane permeabilization by facilitating the recruitment of truncated BID protein to mitochondria
  • may play a role in cellular processes underlying obesity
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • complexing with truncated BID
  • interaction of MTCH2 and tBID is a potential target for therapeutic control of BID initiated cell death
  • binding of BID to MTCH2 suggesting both a quasi-constitutive residence of BID in MTCH2-bound state in healthy cells and its CASP8-mediated cleavage there under apoptotic conditions
  • role for MOAP1 in FAS signaling in the liver by promoting MTCH2-mediated BID recruitment to mitochondria
    • cell & other
    REGULATION
    induced by Met-hepatocytes growth factor/scatter factor (HGF/SF)
    Other up-regulated in NIH-3T3 cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
  • associated with body mass index
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Knockout of MTCH2/MIMP in embryonic stem cells and in mouse embryonic fibroblasts hinders the recruitment of truncated BID protein to mitochondria, the activation of Bax/Bak, mitochondrial outer membrane permeabilization and apoptosis
  • MTCH2/MIMP conditional knockout in liver decreases the sensitivity of mice to Fas-induced hepatocellular apoptosis and prevents the recruitment of tBID to liver mitochondria