basic FUNCTION
| methylates adenosine residues of some mRNAs |
|
may play a role in the efficiencey of mRNA splicing, transport or translation |
|
is sufficient to elicit circadian period elongation and RNA processing delay |
|
is an RNA methyltransferase implicated in mRNA biogenesis, decay, and translation control through N(6)-methyladenosine (m(6)A) modification |
|
important role of METTL3 in promoting translation of oncogenes in human lung cancer |
|
METTL3 is the catalytically active subunit, while METTL14 plays a structural role critical for substrate recognition |
|
METTL3 is the catalytic subunit of the complex, whereas METTL14 has a degenerate active site and plays non-catalytic roles in maintaining complex integrity and substrate RNA binding |
|
controls myeloid differentiation of normal hematopoietic and leukemia cells |
|
critical role of METTL3-mediated N6-methyladenosine (m6A) in regulating the development of mammalian cerebellum |
|
new role for METTL3-mediated N6-methyladenosine (m6A) modification in increasing translation of certain immune transcripts for physiological promotion of dendritic cell (DC) activation and DC-based T cell response |
|
RNA N6-methyladenosine methylase METTL3 inhibits hepatic insulin sensitivity via N6-methylation of FASN mRNA and promoting fatty acid metabolism |
|
required for the epithelial-mesenchymal transition (EMT) process in vitro and for metastasis in vivo |
|
crucial regulator in the progression of osteogenic differentiation |
|
functional importance of METTL3 in osteogenic differentiation |