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FLASH GENE

Symbol

INSM2

contributors: mct - updated : 08-01-2014

HGNC name	insulinoma-associated 2
HGNC id	17539

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q13.2      Physical location : 36.003.247 - 36.006.260
Synonym name	insulinoma-associated protein IA-6
Synonym symbol(s)	mlt1, IA-6

DNA

TYPE	functioning gene
STRUCTURE	3.01 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032594 1 - 3024 NP_115983 - 566 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

five C2H2-type zinc fingers

HOMOLOGY

interspecies

homolog to murine Insm2

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION

may be associated with the transformation of neuroendocrine cells

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

INSM2 plays potentially an important role in the differentiation cascade of NEUROG3/NEUROD1 signaling in pancreatic islets

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS