selectively and stably expressed on the cell surface of T helper 2 (TH2) but not TH1 cells
basic FUNCTION
putatively involved in cell growth
may be induced by proinflammatory stimuli, and may be involved in the function of helper T cells
soluble IL1RL1 suppressed the signal transduction of lipopolysaccharide (LPS) and cytokine production in monocytic cells
soluble IL1RL1 protein was internalized into dendritic cells, suggesting that soluble IL1RL1 protein acts by a noncanonical mechanism other than the sequestration of IL33
IL33/IL1RL1 signaling plays an important role in regulating IL33 induced inflammatory responses in ocular surface
involved in the initiation and perpetuation of inflammation
cell-intrinsic role for the IL33/IL1RL1 axis in the regulation of apoptosis in mast cellls, identifying thereby a previously unappreciated pathway supporting expansion of the mast cellls population with inflammation
IL33/IL1RL1 axis plays an essential role in the development of visceral adipose tissue Treg (VAT-Treg) cells
IL33 and IL1RL1 function as a developmental switch to license thermogenesis during the perinatal period
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
signal transduction
IL33/IL1RL1 pathway is critically involved in mammary tumor growth by facilitating expression of pro-angiogenic VEGFA in tumor cells and attenuating tumor necrosis
IL33/IL1RL1 signaling may be involved in periapical inflammation and tissue fibrosis
a component
INTERACTION
DNA
RNA
small molecule
protein
binding to ILR1LG
GATA2 and GATA1 positively and negatively control human IL1RL1 gene transcription, respectively
TMED1 associates with IL1RL1 (interaction mediated by the GOLD domain of TMED1 and the TIR domain of IL1RL1)
IL33 signals through its ligand-binding primary receptor IL1RL1 and IL1 receptor accessory protein (IL1RAP)
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
Type
Gene Modification
Chromosome rearrangement
Protein expression
Protein Function
constitutional
--over
in sera of SS (Sjogren Syndrome) patients and (Systemic Lupus Erythematosus) patients
constitutional
--over
in patients with greater infarct transmurality and endocardial extent, and in the presence of microvascular obstruction
constitutional
--over
elevated concentrations are predictive of sudden cardiac death in patients with chronic heart failure and provide complementary information to NT-proBNP levels
constitutional
--over
IL33 and IL1RL1 positive cells were also significantly increased in Alzheimer disease (AD) brains when compared to non-AD brains
Susceptibility
to atopic dermatitis
to mild preeclampsia
Variant & Polymorphism
SNP
-26999A allele increase the risk of atopic dermatitis
significantly increased mild preeclampsia risk was observed associated with GG genotype of rs1420103 polymorphisms
Candidate gene
serum levels of the soluble form serve as a biomarker for ventricular biomechanical strain and provide prognostic information in patients who have symptomatic heart failure (Kakkar 2009)
Marker
Therapy target
System
Type
Disorder
Pubmed
cardiovascular
IL33/IL1RL1 not only represents a promising cardiovascular biomarker but also a novel mechanism of intramyocardial fibroblast-cardiomyocyte communication that may prove to be a therapeutic target for the prevention of heart failure
immunology
inflammatory
blockade of IL1RL1 is a novel therapeutic strategy for familial hemophagocytic lymphohistiocytosis (FHL)
ANIMAL & CELL MODELS
Il1rl1 deletion increases inflammatory bone loss in experimental periapical lesions in mice
