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FLASH GENE

Symbol

IRAK1BP1

contributors: mct/pgu - updated : 18-03-2014

HGNC name	interleukin-1 receptor-associated kinase 1 binding protein 1
HGNC id	17368

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q14.1      Physical location : 79.577.188 - 79.608.319
Synonym name	ActA binding protein 3
	signaling molecule that associates with mouse Pelle-like kinase
Synonym symbol(s)	AIP70, SIMPL, 4921528N06Rik, MGC138458, MGC138460

DNA

TYPE	functioning gene
STRUCTURE	31.13 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001010844 4 - 1157 NP_001010844 32.8 295 - 2001 11096118

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N-terminal region predicted to be intrinsically disordered, binding Hsp70/Hsc70 to stabilize the protein and thereby regulate its activity

HOMOLOGY

interspecies

homolog to murine Irak1bp1

Homologene

FAMILY

IRAK1BP1 family

CATEGORY

regulatory , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	nuclear localization is required for type I TNF receptor-induced NF-kappaB activity

basic FUNCTION	signaling component required for tumor necrosis factor alpha (TNF-alpha)-dependent but not interleukin-1-dependent NF-kappaB activation
	regulates transcription of a specific subset of TLR-responsive genes, producing an overall antiinflammatory profile
	critical factor in preventing dangerous overproduction of proinflammatory cytokines by the innate immune system and in influencing the specificity of TLR responses
	required for full TNFSRF1A-dependent expression of NF-kappaB-controlled cytokines in endothelial cells
	down-modulates Toll-like receptor-mediated transcription of several proinflammatory cytokines
	antiinflammatory role in physiologically relevant conditions and promotes up-regulation of IL10 in macrophages
	not only involved directly in down-regulation of inflammatory cytokines but also contributing to the state of LPS-induced tolerance
	inhibits inflammation by promoting nuclear translocation of NFKB1
	is required for full Tumor Necrosis Factor (TNF) induced NFKB activity
	functions as a TNF-dependent p65 co-activator by facilitating the recruitment of MED1 to p65 containing transcriptional complexes to control the expression of a subset of TNF-induced genes
	is found in p65-MED1 complexes where IRAK1BP1 enhances p65/MED1/IRAK1BP1 complex formation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of a signaling pathway through which tumor necrosis factor-alpha (TNF-alpha) induces NF-kappaB-controlled gene transcription

INTERACTION

DNA

RNA

small molecule

protein

interaction between IRAK1BP1 and RELA enhances RELA transactivation activity

cell & other

REGULATION

Other

its phosphorylation plays a critical role in IRAK1BP1 regulation by affecting both IRAK1BP1 subcellular localization and the RELA coactivator function of IRAK1BP1

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS