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FLASH GENE
Symbol NEGR1 contributors: mct - updated : 23-06-2020
HGNC name neuronal growth regulator 1
HGNC id 17302
Location 1p31.1      Physical location : 71.868.625 - 72.748.277
Synonym name
  • a kindred of IgLON
  • neurotractin
  • IgLON family member 4
    • Synonym symbol(s) KILON, MGC46680, Ntra, IGLON4, DMML2433
    DNA
    TYPE functioning gene
    STRUCTURE 879.78 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 5669 - 354 - 1999 10075727
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonamygdala highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal signal sequence
  • three immunoglobulin (Ig)-like C2 domains
  • six putative glycosylation sites
  • a C-terminal GPI anchor attachment site, primarily localized to cell membrane rafts, especially in cell-to-cell contacting areas
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Negr1
    homolog to rattus LOC59318
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • IgLON family
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • neural cell adhesion, signal transduction activity
  • IgLON cell adhesion molecules (CAMs) participate in regulating synapse formation in hippocampal neurons
  • is a raft-associated extracellular protein that may participate in cell recognition and interaction, which is important in growth control and malignant transformation
  • role for all IgLON family members in promoting neurite extension from cortical neurons
  • NEGR1 is involved in both energy balance and behaviour regulation
  • NEGR1 is implicated in obesity and mental disorders
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ADAM10 releases NEGR1 from neuronal membrane
  • potential role for NEGR1 in regulating neurite outgrowth through the modulation of FGFR2 signaling pathway
  • NEGR1 interacts with NPC2 and increases its protein stability
  • NEGR1 and FGFR2 cooperatively regulate cortical development, suggesting a role for defective NEGR1-FGFR2 complex and convergent downstream ERK and AKT signalling in autism spectrum disorders
  • NEGR1 interacts with leukemia inhibitory factor receptor (LIFR) and modulates LIF-induced LCN2 expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to abnormal BMI and neurodevelopment in preschool-age children
    Variant & Polymorphism other
  • cg23166710 was associated with both childhood phenotypes and correlated with NEGR1 placental expression
    • Candidate gene
    Marker
  • increased level of NEGR1 in the frontal cortex may serve as molecular marker for a wider spectrum of psychiatric conditions
    • Therapy target
    ANIMAL & CELL MODELS
  • Negr1 -/- mice had decreased adult hippocampal neurogenesis compared to wild-type mice