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Symbol LSM4 contributors: mct - updated : 07-02-2011
HGNC name LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
HGNC id 17259
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • SM sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop
    • HOMOLOGY
    Homologene
    FAMILY
  • SNRNP SM proteins family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text in isotonic conditions, associates with CLNS1A, and the plasma membrane
    basic FUNCTION
  • involved in mRNA splicing, nuclear mRNA splicing, via spliceosome
  • not only acts in RNA processing, but also as a co-factor in cell volume regulation
    • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the mRNA decay complex (LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CCRN4L, UPF1, UPF2, UPF3B)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CLNS1A interaction partner (in isotonic conditions, LSM4 associates with CLNS1A and the plasma membrane)
  • PATL1 interacting with DCP2/DCP1A, LSM1/LSM4, EDC4, and EDC3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS