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FLASH GENE

Symbol

GPN1

contributors: mct - updated : 03-01-2013

HGNC name	GPN-loop GTPase 1
HGNC id	17030

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Lymphoid/Immune spleen

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular

cell lineage
cell lines	cervical carcinoma
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	nuclear export sequences (NES) sufficient for nuclear export activity, and critical for nucleo-cytoplasmic shuttling and steady-state cytoplasmic localization of GPN1
	a unique GPN loop motif essential, in conjunction with its GTP-binding motifs, for nuclear localization of POLR2A/RPB1 in a process that also requires microtubule assembly

HOMOLOGY

interspecies	homolog to murine Xab1
	homolog to rattus LOC362707
	homolog to Saccharomyces cerevisiae Npa3

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
text	localized to the cytoplasm but it rapidly accumulated in the cell nucleus in the presence of leptomycin B

basic FUNCTION	relieves MBD2-mediated transcriptional repression and reactivates transcription from methylated promoters
	may be involved in nuclear localization of XPA
	GPN1/GPN3 define a new family of small GTPases that are specialized for the transport of RNA polymerase II into the nucleus
	GTPase that associates with RNA polymerase II (RNAPII) in a GTP-dependent manner

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

potential unconventional pathway for nuclear import of RNAPII, which involves GTP-dependent binding of GPN1 to the polymerase

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP binding
	GTP binding

protein	interacting with XPA
	shuttles between the nucleus and the cytoplasm and regulates nuclear import of POLR2A/RPB1 and POLR2B/RPB2, the two largest subunits of RNAPII

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS