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FLASH GENE
Symbol RRAGA contributors: mct - updated : 21-10-2016
HGNC name Ras-related GTP binding A
HGNC id 16963
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three phosphate/magnesium binding motifs PM1, PM2, PM3
  • a guanine-nucleotide binding motif G1
  • a switch regions of the G domain indispensible for interaction with raptor, and hence MTOR activation
  • dimerized C-terminal domains of RRAGA-RRAGC display a remarkable structural similarity to LAMTOR3, which is in a complex with lysosome membrane protein LAMTOR1, and directly interact with LAMTOR1, therefore recruiting MTORto the lysosome for activation by RHEB
    • HOMOLOGY
    interspecies homolog to murine Rraga
    homolog to rattus Raga
    homolog to yeast GTR1
    homolog to C.elegans ceT24F1
    Homologene
    FAMILY Ras-like small G protein family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    intracellular,nucleus,nucleoplasm
    text near the nuclear membrane and the plasma membrane
    basic FUNCTION
  • GTPase activity
  • may have a direct role as a TNF-alpha signal transducer
  • may be involved in the TNF-alpha cytolysis pathway
  • do not directly stimulate the kinase activity of MTOR, but, like amino acids, promote the intracellular localization of MTOR to a compartment that also contains its activator RHEB
  • have a critical role in nutrient sensing by MTOR and in neonatal survival during fasting
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • RRAGA forms a heterodimer with other G proteins, RRAGC and RRAGD, in a nucleotide-independent manner
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP binding
    protein
  • cellular target for adenovirus 14.7kDa E3 protein (E3-14.7K)
  • NOL8 is associated with the GTP form, but not the GDP form, of RRAGA, suggesting that RRAGA might regulate NOL8 function
  • bind raptor and mediate amino acid signaling to MTOR
  • a complex encoded by the LAMTOR1, LAMTOR2, LAMTOR3 genes, which we term Ragulator, interacts with the RRAGA, RRAGB, RRAGC, RRAGD, recruits them to lysosomes, and is essential for MTOR activation
  • recently identifed as a negative regulator of Rag GTPases (RRAGA, RRAGB, RRAGC, RRAGD)
  • WDR35 is associated with RRAGA, RRAGB, RRAGC and might negatively influence MTOR activity
    • cell & other
    REGULATION
    activated by TNF-alpha
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS