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FLASH GENE

Symbol

RRAGA

contributors: mct - updated : 21-10-2016

HGNC name	Ras-related GTP binding A
HGNC id	16963

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver         Endocrine adrenal gland       highly Lymphoid/Immune spleen           thymus         Nervous brain       highly Reproductive female system ovary         male system testis       Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol not specific adipocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three phosphate/magnesium binding motifs PM1, PM2, PM3
	a guanine-nucleotide binding motif G1
	a switch regions of the G domain indispensible for interaction with raptor, and hence MTOR activation
	dimerized C-terminal domains of RRAGA-RRAGC display a remarkable structural similarity to LAMTOR3, which is in a complex with lysosome membrane protein LAMTOR1, and directly interact with LAMTOR1, therefore recruiting MTORto the lysosome for activation by RHEB

HOMOLOGY

interspecies	homolog to murine Rraga
	homolog to rattus Raga
	homolog to yeast GTR1
	homolog to C.elegans ceT24F1

Homologene

FAMILY

Ras-like small G protein family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,lysosome
	intracellular,nucleus,nucleoplasm
text	near the nuclear membrane and the plasma membrane

basic FUNCTION	GTPase activity
	may have a direct role as a TNF-alpha signal transducer
	may be involved in the TNF-alpha cytolysis pathway
	do not directly stimulate the kinase activity of MTOR, but, like amino acids, promote the intracellular localization of MTOR to a compartment that also contains its activator RHEB
	have a critical role in nutrient sensing by MTOR and in neonatal survival during fasting

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

RRAGA forms a heterodimer with other G proteins, RRAGC and RRAGD, in a nucleotide-independent manner

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP binding

protein	cellular target for adenovirus 14.7kDa E3 protein (E3-14.7K)
	NOL8 is associated with the GTP form, but not the GDP form, of RRAGA, suggesting that RRAGA might regulate NOL8 function
	bind raptor and mediate amino acid signaling to MTOR
	a complex encoded by the LAMTOR1, LAMTOR2, LAMTOR3 genes, which we term Ragulator, interacts with the RRAGA, RRAGB, RRAGC, RRAGD, recruits them to lysosomes, and is essential for MTOR activation
	recently identifed as a negative regulator of Rag GTPases (RRAGA, RRAGB, RRAGC, RRAGD)
	WDR35 is associated with RRAGA, RRAGB, RRAGC and might negatively influence MTOR activity

cell & other

REGULATION

activated by

TNF-alpha

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS