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FLASH GENE

Symbol

CREB5

contributors: - updated : 20-02-2004

HGNC name	cAMP responsive element binding protein 5
HGNC id	16844

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	407.00 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence

Binding site   cAMP

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	three alternatively spliced variants

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CREB5 variant 1 - - 2637 isoform alpha 56 508 - Nomura CREB5 variant 2 - splicing 2293 isoform gamma 53 475 - Nomura CREB5 variant 3 - splicing 2319 isoform beta - - - Nomura

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system ovary

cell lineage
cell lines	HelaS3, KATOIII, 253J
fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	placenta, fetal brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	bZIP transcription factor motif
	zinc finger C2H2 type

mono polymer

homomer , heteromer , dimer

HOMOLOGY

interspecies

homolog to murine Creb5

intraspecies

homolog to ATF2

Homologene

FAMILY

bZIP family, ATF subfamily

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

transcriptional activator on binding to the cAMP responsive region (cre)

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binds DNA as a dimer and can form homodimer in the absence of DNA

RNA

small molecule

protein

can form an heterodimer with c-jun or ATF2

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS