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FLASH GENE

Symbol

TP53I11

contributors: - updated : 07-02-2006

HGNC name	tumor protein p53 inducible protein 11
HGNC id	16842

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11pter-p15.5      Physical location : 44.953.899 - 44.972.608
Synonym name	p53-induced protein
Synonym symbol(s)	PIG11

DNA

TYPE	functioning gene
STRUCTURE	47.00 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   transcription factor
text structure	a p53 binding site

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue       Lymphoid/Immune spleen         Nervous brain         Reproductive male system testis       Urinary kidney         Visual eye

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	ortholog to murine Trp53i11
	ortholog to rattus Tp53i11_predicted

Homologene

FAMILY

CATEGORY

tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	could induce cell apoptosis and enhanced the apoptotic effects of arsenic trioxide when overexpressed
	involved in intracellular generation of ROS
	negative regulation of cell proliferation
	involved in apoptosis of gastric cancer cells
	may play an important role by interaction with other biological molecules in the regulation of apoptosis

CELLULAR PROCESS	cell life, proliferation/growth
	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by

P53

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in some hepatocellular carcinoma tumoral         in some hepatocellular carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS