Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TGFBRAP1 contributors: mct - updated : 30-08-2011
HGNC name transforming growth factor, beta receptor associated protein 1
HGNC id 16836
Location 2q12.1      Physical location : 105.883.541 - 105.946.148
Synonym symbol(s) TRAP-1, TRAP1
DNA
TYPE functioning gene
STRUCTURE 62.62 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
IL1RL1 2q12 interleukin 1 receptor-like 1 IL18R1 2q12 interleukin 18 receptor 1 IL18RAP 2p24.3-p24.1 interleukin 18 receptor accessory protein LOC389015 2 similar to Sodium/hydrogen exchanger 4 (Na(+)/H(+) exchanger 4) (NHE-4) SLC9A2 2q11.2 solute carrier family 9 (sodium/hydrogen exchanger), isoform 2 MGC11332 2q12.1 hypothetical protein MGC11332 FLJ30294 2q12.1 hypothetical protein FLJ30294 LOC130822 2q12.1 similar to cytokine receptor-like factor 3; cytokine receptor-like molecule 9; cytokine receptor related protein 4 LOC391413 2 similar to Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) LOC391414 2 similar to high mobility group protein homolog HMG4 POU3F3 3p14.2 POU domain, class 3, transcription factor 3 MRPS9 2q12.1 mitochondrial ribosomal protein S9 GPR45 2q11.2-q12 G protein-coupled receptor 45 TGFBRAP1 2q12.1 transforming growth factor, beta receptor associated protein 1 MGC5509 2q12.2 hypothetical protein MGC5509 FHL2 2q12-q13 four and a half LIM domains 2 NCK2 2q12 NCK adaptor protein 2 ECRG4 2q12.2 esophageal cancer related gene 4 protein UXS1 2q12.1 UDP-glucuronate decarboxylase 1 LOC391415 2 similar to ribosomal protein S21; 40S ribosomal protein S21 LOC391416 2 similar to hypothetical protein MGC4614 LOC389016 2 similar to RAN-binding protein 2-like 1 isoform 1; sperm membrane protein BS-63; RAN-binding protein 2-like 1 LOC391417 2 similar to anaphase-promoting complex 1 (meiotic checkpoint regulator) CD8B2 2q12 CD8 antigen, beta polypeptide 2, pseudogene (p37) LOC389017 2 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) LOC389018 2 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) ST6GalII 2q11.2-q12.1 beta-galactoside alpha-2,6-sialyltransferase II LOC339819 2q12.3 similar to protein phosphatase 1, regulatory (inhibitor) subunit 2 DKFZp686P0288 2q12.3 similar to Ran-binding protein 2 SLC5A7 2q12 solute carrier family 5 (choline transporter), member 7 LOC391418 2 similar to phenol sulfotransferase SULT1C1 2q11.1-q11.2 sulfotransferase family, cytosolic, 1C, member 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2975 - 860 - 2001 11278302
12 - 2978 - 860 - 2001 11278302
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
multiple phosphorylation and myristoylation sites
HOMOLOGY
interspecies homolog to murine 3110018K12Rik
homolog to rattus LOC301373
Homologene
FAMILY
CATEGORY chaperone/stress , receptor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
basic FUNCTION
  • receptor activity in the TGFB receptor signaling pathway
  • a partial cDNA of TGFBRAP1 could act as an inhibitor of TGFB signaling pathway
  • with VPS39, are nonredundant and essentially required for early embryonic development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with TGFBR2, SMAD4 and activated TGFBR1
  • four candidate target genes for NO66, SBNO1, TGFBRAP1, RIOK1, and RASGEF1A, which were the most significantly induced by exogenous NO66 expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS