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FLASH GENE

Symbol

PHOSPHO1

contributors: mct/npt - updated : 07-12-2016

HGNC name	phosphatase, orphan 1
HGNC id	16815

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed PHOSPHO1-3a 3 - 879 - 292 osteoblasts Roberts (2008) 40 amino acid N-terminal region contains a relatively strong secretory signal, however all three domains of the HAD superfamily are retained in exon 3 variant 1 3 - 2070 - 267 - Roberts (2008)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone periosteum   highly

cells

System Cell Pubmed Species Stage Rna symbol   chondrocyte Skeleton osteoblast

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a VWFC domain

mono polymer

homomer , monomer

HOMOLOGY

interspecies

homolog to murine Phospho1

Homologene

FAMILY	fibrillar collagen family
	haloacid dehalogenase superfamily of Mg2+-dependent hydrolases

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,interspace
	intracellular,cytoplasm,cytosolic,vesicle
text	localized to sites of mineralisation in both cartilage and bone, in matrix vesicules

basic FUNCTION	phosphatase capable of cleaving phosphoethanolamine (PEA) and phosphocholine to generate inorganic phosphate (Roberts 2007)
	phosphoethanolamine/phosphocholine phosphatase that has previously been implicated in generating inorganic phosphate (P(i)) for matrix mineralization
	implicated in the mineralization process in both osteoblasts and chondrocytes
	exhibiting high specific activities toward phosphoethanolamine (PEA) and phosphocholine (PCho)
	has a role in the mineralization process which is likely to be in the production of Pi for calcium phosphate precipitation
	plays a role in the initiation of matrix mineralization (Roberts 2007)
	prominent non-redundant roles for both PHOSPHO1 and ALPL in dentin mineralization

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

glycerophospholipid metabolism

a component

homotrimers of alpha 1(II) chains

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS