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FLASH GENE
Symbol PHOSPHO1 contributors: mct/npt - updated : 07-12-2016
HGNC name phosphatase, orphan 1
HGNC id 16815
Location 17q21.32      Physical location : 47.300.731 - 47.308.128
Synonym name phosphoethanolamine/phosphocholine phosphatase
EC.number 3.1.3.75
DNA
TYPE functioning gene
STRUCTURE 7.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 879 - 292 osteoblasts Roberts (2008)
40 amino acid N-terminal region contains a relatively strong secretory signal, however all three domains of the HAD superfamily are retained in exon 3
3 - 2070 - 267 - Roberts (2008)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveboneperiosteum highly
cells
SystemCellPubmedSpeciesStageRna symbol
 chondrocyte
Skeletonosteoblast
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a VWFC domain
    • mono polymer homomer , monomer
    HOMOLOGY
    interspecies homolog to murine Phospho1
    Homologene
    FAMILY
  • fibrillar collagen family
  • haloacid dehalogenase superfamily of Mg2+-dependent hydrolases
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,cytosolic,vesicle
    text localized to sites of mineralisation in both cartilage and bone, in matrix vesicules
    basic FUNCTION
  • phosphatase capable of cleaving phosphoethanolamine (PEA) and phosphocholine to generate inorganic phosphate (Roberts 2007)
  • phosphoethanolamine/phosphocholine phosphatase that has previously been implicated in generating inorganic phosphate (P(i)) for matrix mineralization
  • implicated in the mineralization process in both osteoblasts and chondrocytes
  • exhibiting high specific activities toward phosphoethanolamine (PEA) and phosphocholine (PCho)
  • has a role in the mineralization process which is likely to be in the production of Pi for calcium phosphate precipitation
  • plays a role in the initiation of matrix mineralization (Roberts 2007)
  • prominent non-redundant roles for both PHOSPHO1 and ALPL in dentin mineralization
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    glycerophospholipid metabolism
    a component
  • homotrimers of alpha 1(II) chains
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS