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FLASH GENE
Symbol SPACA3 contributors: mct - updated : 27-03-2020
HGNC name sperm acrosome associated 3
HGNC id 16260
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a protease cleavage site
  • a putative transmembrane region
  • three putative myristoylation sites
  • two potential phosphorylation sites
    • isoforms Precursor 128 aa and 14.6kDa for the mature form
    HOMOLOGY
    Homologene
    FAMILY alpha-lactalbumin/lysozyme C family
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text
  • in the acrosome of ejaculated sperm
  • localizes in the sperm acrosome
    • basic FUNCTION
  • potential receptor for egg oligosaccharide residue N-acetylglucosamine
  • may have a role in sperm/egg adhesion
  • is associated with sperm-oocyte recognition and binding, and may play a role in fertility
  • has a role in female fertility
  • may have a role in sperm function, innate immunity and other physiological process as well
  • role of SPACA3 and LYZL4 in fertilization
  • contribute to fertilization but show no bacteriolytic activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ASTL is identified as a SPACA3 binding partner
  • exhibits high affinity for an oolemmal receptor, ASTL
  • SPACA3, LYZL4 and SPACA5 possess hyaluronan binding ability
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    represents a promising target for the immunotherapy of multiple myeloma (MM), in particular for the adoptive transfer of T cell receptor-transduced T cells
    ANIMAL & CELL MODELS
  • female mice immunized with Sprasa had profound infertility following timed matings and those mice that did become pregnant had reduced fetal viability