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FLASH GENE
Symbol SPACA3 contributors: mct - updated : 27-03-2020
HGNC name sperm acrosome associated 3
HGNC id 16260
Location 17q11.2      Physical location : 31.318.881 - 31.324.892
Synonym name
  • sperm lysozyme like protein 1
  • lysozyme-like sperm-specific secretory protein ALLP17
  • cancer/testis antigen 54
  • lysozyme C
  • lysozyme-like protein 3
  • Sperm protein reactive with antisperm antibody
    • Synonym symbol(s) LYC3, LYZL3, SLLP1, ALLP17, CT54, LYZC, MGC119058, SPRASA
    DNA
    TYPE functioning gene
    STRUCTURE 6.03 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 839 - 215 - 2005 16014814
    4 - 530 - 112 - 2005 16014814
    5 - 905 - 123 - 2005 16014814
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary    Homo sapiens
     male systemtestis  specific
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegranulosa cell Homo sapiens
    Reproductiveoocyte Homo sapiens
    Reproductivespermatozoa
    cell lineage
    cell lines Burkitt lymphoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a protease cleavage site
  • a putative transmembrane region
  • three putative myristoylation sites
  • two potential phosphorylation sites
    • isoforms Precursor 128 aa and 14.6kDa for the mature form
    HOMOLOGY
    Homologene
    FAMILY alpha-lactalbumin/lysozyme C family
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text
  • in the acrosome of ejaculated sperm
  • localizes in the sperm acrosome
    • basic FUNCTION
  • potential receptor for egg oligosaccharide residue N-acetylglucosamine
  • may have a role in sperm/egg adhesion
  • is associated with sperm-oocyte recognition and binding, and may play a role in fertility
  • has a role in female fertility
  • may have a role in sperm function, innate immunity and other physiological process as well
  • role of SPACA3 and LYZL4 in fertilization
  • contribute to fertilization but show no bacteriolytic activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ASTL is identified as a SPACA3 binding partner
  • exhibits high affinity for an oolemmal receptor, ASTL
  • SPACA3, LYZL4 and SPACA5 possess hyaluronan binding ability
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    represents a promising target for the immunotherapy of multiple myeloma (MM), in particular for the adoptive transfer of T cell receptor-transduced T cells
    ANIMAL & CELL MODELS
  • female mice immunized with Sprasa had profound infertility following timed matings and those mice that did become pregnant had reduced fetal viability