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FLASH GENE
Symbol HCLS1 contributors: mct - updated : 29-08-2022
HGNC name hematopoietic cell-specific Lyn substrate 1
HGNC id 4844
DNA
TYPE functioning gene
STRUCTURE 29.50 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2050 - 486 - 2019 30537294
13 - 1881 - 449 - 2019 30537294
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 spleen   highly
 thymus   highly
 tonsils   highly
cell lineage hematopoietic cell lineage
cell lines
fluid/secretion lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • at least three N terminal HS1 repeats
  • a helix-turn-helix DNA binding domain
  • a C terminal SH3 domain
  • several potential phosphorylation sites
  • two clusters of potential caspase cleavage sites
  • four cortactin repeats
  • secondary structure at least six N terminal alpha helices
    conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Hcls1
    homolog to Drosophila cortactin
    homolog to C.elegans Y45F10D.13
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • substrate of the antigen recepto-coupled tyrosine kinase, playing a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells
  • substrate of caspase 3 (degradation in a caspase-dependent manner during apoptosis)
  • is a central regulator of cytoskeleton remodeling that controls lymphocyte trafficking and homing and significantly influences the tissue invasion and infiltration in CLL
  • cytoskeletal interactor in the B-cell receptor (BCR) signaling pathway whose phosphorylation correlates with prognosis in Chronic Lymphocytic Leukemia (CLL)
  • is important for the activation of GTPases and integrins, and mediates signaling downstream of many receptors including BCR, TCR, and CXCR4
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • forms a multiprotein complex with ANKRD54 and LYN in erythroid cells (Samuels 2009)
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding to HAX1 and to the SH2 and SH3 domains of HS1BP3
  • HS1BP3 regulates apoptosis via HCLS1 and stimulates JUN-mediated transcription
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in ovarian tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS