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FLASH GENE

Symbol

ANKRD1

contributors: mct - updated : 31-08-2018

HGNC name	ankyrin repeat domain 1 (cardiac muscle)
HGNC id	15819

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         is expressed in the majority of ovarian adenocarcinomas and higher tumor levels of ANKRD1 are found in patients with worse outcome (Scutt 2008) constitutional     --over   up-regulated in some muscle diseases including muscular dystrophy and myopathy (Matsuura 2007) constitutional     --over   tended to be induced in cases exhibiting nephrotic syndrome, and may be correlated with the severity of proteinuria in lupus nephritis (Matsuura 2007) constitutional     --over   exacerbates pathological cardiac dysfunction through enhancement of cardiomyocyte apoptosis mediated by the up-regulation of TP53

Susceptibility

Variant & Polymorphism

Candidate gene	for total anomalous pulmonary venous return (TAPVR2)
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive ovary potential molecular target to enhance sensitivity of ovarian cancer to chemotherapy cardiovascular cardiomyopathy   is an anti-hypertrophic factor in therapy of cardiac hypertrophy

ANIMAL & CELL MODELS