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FLASH GENE
Symbol MUC15 contributors: - updated : 15-04-2004
HGNC name mucin 15
HGNC id 14956
Location 11p14.3      Physical location : 26.580.579 - 26.593.815
DNA
TYPE functioning gene
STRUCTURE 12.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC203859 11p15.1 hypothetical protein LOC203859 SLC17A6 11p14.3 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 FANCF 11p15 Fanconi anemia, complementation group F GAS2 11p15.2-p14.3 growth arrest-specific 2 LOC196188 11p14.3 similar to ribosomal protein S2 LOC341002 11p14.3 similar to dJ568F9.1 (zinc finger protein 133 (clone pHZ-13)) LOC338645 11p14.3 hypothetical protein LOC338645 LOC390103 11 similar to amyloid beta precursor protein-binding protein 1; amyloid protein-binding protein 1 TMEM16C 11p14.3 transmembrane protein 16C MUC15 11p14.3 mucin 15 MGC52019 11p14.3 hypothetical protein MGC52019 LOC387758 11 similar to RIKEN cDNA 1110018M03 BBOX1 11p14.1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 NY-REN-41 11p14.2 NY-REN-41 antigen GPR48 11p14-p13 G protein-coupled receptor 48 LIN7C 11p14 lin-7 homolog C (C. elegans) LOC283114 11p14.2 similar to 40S ribosomal protein S25 BDNF 11p14 brain-derived neurotrophic factor LOC159770 11p14.1 chromobox homolog 3 gamma pseudogene HSPCAL3 11p14.2-p14.1 heat shock 90kDa protein 1, alpha-like 3 DKFZP434G2226 11p14.1 kinesin family member 18A FLJ33979 11p14.1 hypothetical protein FLJ33979 LOC390104 11 similar to eukaryotic translation elongation factor 1 alpha 1-like 14 KCNA4 11p14.1 potassium voltage-gated channel, shaker-related subfamily, member 4 FSHB 11p13 follicle stimulating hormone, beta polypeptide FLJ38968 11p14.1 hypothetical protein FLJ38968 C11orf8 11p13 chromosome 11 open reading frame 8 LOC387759 11 LOC387759 FLJ46154 11p14.1 FLJ46154 protein LOC341019 HCP25 11p13 cytochrome c, somatic pseudogene LOC120526 11p14.1 hypothetical protein LOC120526 FLJ25059 11p14.1 hypothetical protein FLJ25059 ELP4 11p13 elongation protein 4 homolog (S. cerevisiae) PAX6 11p13 paired box gene 6 (aniridia, keratitis)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus    
Digestiveintestinelarge intestinecolon  
 intestinesmall intestine   
 intestinelarge intestine   
Hearing/Equilibriumearinnercochlea  
Lymphoid/Immunetonsils    
Reproductivefemale systembreast   
 female systembreastmammary gland  
 female systemovary   
 male systemprostate   
 male systemtestis   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Respiratoryepithelial cell
cell lineage
cell lines
fluid/secretion milk
at STAGE
physiological period fetal, pregnancy
Text placenta, liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal peptide signal
  • an extracellular N-terminal region rich in ser, thr, pro, leu, and asn residues
  • a transmembrane domain
  • containing numerous potential glycosylation sites (O and N types)
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to bovine Muc15
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • required to mediate mannosylphosphate transfer in both the core and outer chain portions of N-linked oligosaccharides
  • provides a physical barrier protecting the underlying epithelium
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS