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FLASH GENE
Symbol NETO2 contributors: mct - updated : 20-12-2014
HGNC name neuropilin (NRP) and tolloid (TLL)-like 2
HGNC id 14644
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain
  • a transmembrane domain
  • an intracellular FXNPXY-like motif, which has been shown in other proteins to be essential for the internalization of clathrin coated pits during endocytosis
    • HOMOLOGY
    interspecies homolog to murine Neto2
    intraspecies homolog to NETO1
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • implicated in intracellular signaling pathway
  • having roles during development of the central nervous system
  • kainate receptor subunit with significant effects on glutamate signaling mechanisms in brain
  • involved in neural and vascular patterning
  • have marked effects on receptor properties, increasing further the potential diversity of KAR (Kainate receptor) functional properties
  • NETO1, and NETO2 are auxiliary subunits that determine key properties of native kainate receptors
  • NETO1, and NETO2 transmembrane proteins alter the trafficking, channel kinetics, and pharmacology of the receptors in a subunit-dependent manner
  • is a SLC12A5 interacting protein required for neuronal Cl- regulation in hippocampal neurons
  • NETO1 and NETO2 auxiliary subunits coassemble with NMDA receptors (NMDARs) and kainate receptors (KARs) to modulate their function
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interactor with kainate-type glutamate receptors
  • modulates the gating kinetics of GRIK2, and the function of most kainate receptors
  • in neurons, kainate receptors can associate with the auxiliary subunits NETO1 or NETO2
  • is required to maintain the normal abundance of SLC12A5 and specifically associates with the active oligomeric form of the transporter)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in proliferating hemangiomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS