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FLASH GENE

Symbol

NETO2

contributors: mct - updated : 20-12-2014

HGNC name	neuropilin (NRP) and tolloid (TLL)-like 2
HGNC id	14644

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018092 9 - 3653 NP_060562 - 525 - 2002 11943477

EXPRESSION

Rna function	mRNAs were observed restrictively in brain throughout embryonic and postnatal stages, uniquely in the pontine nucleus and subplate, which are required for establishing the neuronal circuit formation
Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain cerebral lobe frontal   Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain
	a transmembrane domain
	an intracellular FXNPXY-like motif, which has been shown in other proteins to be essential for the internalization of clathrin coated pits during endocytosis

HOMOLOGY

interspecies

homolog to murine Neto2

intraspecies

homolog to NETO1

Homologene

FAMILY

CATEGORY

signaling

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	implicated in intracellular signaling pathway
	having roles during development of the central nervous system
	kainate receptor subunit with significant effects on glutamate signaling mechanisms in brain
	involved in neural and vascular patterning
	have marked effects on receptor properties, increasing further the potential diversity of KAR (Kainate receptor) functional properties
	NETO1, and NETO2 are auxiliary subunits that determine key properties of native kainate receptors
	NETO1, and NETO2 transmembrane proteins alter the trafficking, channel kinetics, and pharmacology of the receptors in a subunit-dependent manner
	is a SLC12A5 interacting protein required for neuronal Cl- regulation in hippocampal neurons
	NETO1 and NETO2 auxiliary subunits coassemble with NMDA receptors (NMDARs) and kainate receptors (KARs) to modulate their function

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interactor with kainate-type glutamate receptors
	modulates the gating kinetics of GRIK2, and the function of most kainate receptors
	in neurons, kainate receptors can associate with the auxiliary subunits NETO1 or NETO2
	is required to maintain the normal abundance of SLC12A5 and specifically associates with the active oligomeric form of the transporter)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in proliferating hemangiomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS