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FLASH GENE
Symbol MXD3 contributors: mct/npt - updated : 06-04-2010
HGNC name MAX dimerization protein 3
HGNC id 14008
DNA
TYPE functioning gene
STRUCTURE 6.80 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2662 - 193 - Yun (2007)
6 - 1483 - 206 - Yun (2007)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, S
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one helix-loop-helix domain
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Mxd3 (85 pc)
    Homologene
    FAMILY
  • bHLH family of transcription factor
  • MAD family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text expressed specifically during the S-phase of the cell cycle in both proliferating and differentiating cells (Fox 2003)
    basic FUNCTION
  • represses transcription, when bound to MAX protein
  • necessary role for SHH-dependent granule neuron precursors proliferation (Yun 2007)
  • should antagonize MYCN by competition for direct DNA binding via Max dimerization (Yun 2007)
  • may be having a role in cellular proliferation and tumorigenesis (Barisone 2008)
  • promotes the segregation of nonexchange chromosomes that are not tethered by SLC39A1 at their centromeresb (Newnhan 2010)
  • negatively regulates B cell differentiation in the spleen by inducing ID2 expression
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with MAX
  • interacts with other DNA binding proteins to repress transcription (Yun 2007)
  • transcriptional target of E2F1 (Fox 2003)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS