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FLASH GENE

Symbol

FBXW5

contributors: mct/npt/pgu - updated : 13-12-2016

HGNC name	F-box and WD repeat domain containing 5
HGNC id	13613

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	anonymous DNA segment
STRUCTURE	4.29 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	three alternatively spliced variants

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 9 splicing 2387 isoform 1 63 566 - 1999 10531037 the longest isoform variant 2 - splicing 2456 isoform 2 - 261 - 1999 10531037 contains an additional segment in the coding region resulting in a frameshift and an earlier translation termination (compared to variant 1) isoform 2 is shorter and has a distinct C-terminus variant 3 - splicing 2379 isoform 3 - 213 - 1999 10531037 contains an additional segment (resulting in a frameshift and an earlier translation termination) and also lacks a downstream segment in the coding region (compared to variant 1) isoform 3 is shorter and has a distinct C-terminus

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Reproductive female system ovary         female system uterus cervix       male system testis       Skin/Tegument skin

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminally located F-box motif (F-box motif functions to bridge a substrate protein to the CUL1
	ROC1 E3 ligase via the SKP1 linker)
	seven WD40 repeats occupying most of the rest of the sequence

mono polymer

complex

HOMOLOGY

interspecies

homolog to murine Fbxw5

Homologene

FAMILY

F-box protein family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	localized to both nucleus and cytosol

basic FUNCTION	probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation
	negatively regulates MAP3K7 in the IL1B signaling pathway
	cell-cycle-regulated protein with expression levels peaking at the G1/S transition
	FBXW5 is a substrate of both PLK4 and APC/C, two established regulators of centriole duplication
	enhances sumoylation of MYB in the nucleus, which suppresses MYB activity
	FBXW5 may adopt a different protein conformation when interacting with TSC2 or MYB, which may selectively induce binding to ubiquitin or SUMO ligase components

CELLULAR PROCESS	protein, degradation
	protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	part of a SCF protein ligase complex
	component of the IL-1B-induced MAP3K7 complex

INTERACTION

DNA

RNA

small molecule

protein	interacts with SKP1A
	binds to TSC2 (TSC2 is recruited by FBXW5 to the DDB1/CUL4/ROC1 E3 ubiquitin ligase)
	also binds to TSC1
	binds SASS6 and promotes its ubiquitylation
	substrate of both PLK4 and CDC20, two established regulators of centriole duplication
	FBXW5 control the degradation of the centriole assembly factor SASS6
	FBXW5 enhanced sumoylation of nuclear MYB and induced the localization of MYB to nuclear dot-like domains
	FBXW5-driven fluctuation of EPS8 levels is an important mechanism that contributes to cell-shape changes during entry into-and exit from-mitosis
	is a TSC2 binding receptor within CUL4 E3 ligase complex, and it promotes proteasomal degradation of TSC2

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS