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FLASH GENE

Symbol

PTPRN

contributors: mct - updated : 19-09-2018

HGNC name	protein tyrosine phosphatase, receptor type, N
HGNC id	9676

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     deletion of PTPRN, PTPRN2, structural proteins of secretory vesicles and modulators of neuroendocrine secretion, has a profound effect on the circadian system

Susceptibility

to insulin dependent diabetes mellitus encoding an autoantigen

Variant & Polymorphism

Candidate gene
Marker	with PTPRN2 are closely related proteins that were first identified as targets of autoantibodies in Type I diabetics (Caromile 2010)
Therapy target

ANIMAL & CELL MODELS